教育经历：
2013.09-2016.12 |
巴黎人官方网站，药学院，药剂学系，博士 |
导师：丁劲松 |
2014.10-2016.09 |
University of Waterloo；国家公派联合培养博士 |
导师：Juewen Liu |
2014.02-2014.09 |
University of Waterloo；访问博士 |
导师：Juewen Liu |
2010.09-2013.06 |
巴黎人官方网站，药学院，药剂学系，硕士 |
导师：丁劲松 |
2006.09-2010.06 |
巴黎人官方网站，药学院，学士 |
|
工作经历：
2017.03-至今 巴黎人官方网站 教授
研究领域：
Ø 应用基础研究：
基于金属的新药开发及制剂研究；功能核酸的基础与应用研究
Ø 应用研究：基于纳米的新医疗器械研发
人才项目：
湖南省科技人才托举工程，年轻优秀科技人才，湖南省科协，2020年
湖南省优秀青年基金，肿瘤药剂学，湖南省科技厅，2021年
湖湘青年英才，湖南省科技厅，2021年
科研成果：
Ø 主持科研项目：
纵向项目
国家自然科学基金，可突破免疫屏障的“隐形”沙门氏菌联合放疗免疫增敏用于宫颈癌的治疗研究
国家自然科学基金，基于功能核酸串联的诊疗一体化探针的构建与应用研究
横向项目
硫酸羟氯喹片生物等效性预试验合作研究
SM-1细胞活性与细胞内Procaspase-3酶原含量的相关性研究
一种用于抗胰腺癌的纳米制剂开发
一种用于抗乳腺癌的纳米制剂开发
一种机械纳米材料的研制及其质量评价
先必新和恩必普对缺血性脑卒中的疗效比较
应用Crispr-Cas9全基因文库筛选与胰腺癌耐药相关的关键基因
共载雄黄和伊马替尼的白蛋白靶向纳米粒用于慢性粒细胞白血病的治疗研究
对比先必新和恩必普对缺血性脑卒中脑血流动力学影响
应用Crispr-Cas9全基因文库筛选与胰腺癌耐药相关的关键基因
多色免疫荧光试剂盒应用开发
小分子化合物LN020非临床研究
Ø 授权发明专利：
纳米配位聚合物及其制备方法和应用，ZL 201910805848.4，排名第一，授权公告日：2020年06月23号
一种抑制活化巨噬细胞增殖的聚合物/银活性键合物及其制备和应用，ZL 201910374069.3，排名第一，授权公告日：2020年06月16号（已转让）
一种酸性环境中可降解的表面涂层及其制备方法与应用，ZL 202010675017.2，排名第一，授权公告日：2021年04月13日
一种电荷可控的聚合物材料及其制备方法与应用，ZL 202010676053.0，排名第一，授权公告日：2021年07月23日
一种DNA/纳米复合物及其制备方法与应用，ZL 202110041560.1，排名第一，授权公告日：2022年06月28日
包载甲氨蝶呤的铁-鞣酸配合物及其制备方法和应用，ZL202010903340.0，排名第一，授权公告日：2020年08月12日
核酸检测探针及其制备方法，排名第二，ZL 202110532356，授权公告日：2021-08-24
Ø 科研奖励：
湖南省自然科学奖二等奖，金属离子特异性功能核酸的筛选、表征及应用，排名第一
Ø 发表论文：以第一/通讯作者身份在国际著名学术期刊Chemical Reviews, ACS Nano, Nano letters, Biomaterials, Materials Horizons, Nucleic Acids Research等累计发表SCI学术论文70余篇。
代表性论文
1. Jiaojiao Zhu+, Ruimin Chang+, Benliang Wei, Yao Fu, Xiang Chen*, Hong Liu*, and Wenhu Zhou*, Photothermal Nano-Vaccine Promoting Antigen Presentation and Dendritic Cells Infiltration for Enhanced Immunotherapy of Melanoma via Transdermal Microneedles Delivery, Research, 2022, DOI：10.34133/2022/9816272
2. Jiahao Liu#, Lina Guo#, Ze Mi, Liu Zhenguo, Pengfei Rong* and Wenhu Zhou*, Vascular Bursts-Mediated Tumor Accumulation and Deep Penetration of Spherical Nucleic Acids for Synergistic Radio-Immunotherapy, Journal of Controlled Release, 2022, 348, 1050-1065
3. Ze Mi#, Qing Yao#, Yan Qi, Jinhai Zheng, Jiahao Liu, Zhenguo Liu, Hongpei Tan, Xiaoqian Ma, Wenhu Zhou*, Pengfei Rong*, Salmonella-Mediated Blood-Brain Barrier Penetration, Tumor Homing and Tumor Microenvironment Regulation for Enhanced Chemo/Bacterial Glioma Therapy, Acta Pharmaceutica Sinica B, 2022, in press
4. Shengmei Wang1,4#, Xuanjun Liu1,2#, Minghua Yang3, Linqi Ouyang4, Jinsong Ding2, Shengfeng Wang*1,2,3, and Wenhu Zhou*, Non-cytotoxic Nanoparticles Re-educating Macrophages Achieving both Innate and Adaptive Immune Responses for Tumor Therapy, Asian Journal of Pharmaceutical Sciences, 2022, 17 (4) 557-570
5. Yingcai Meng, Jiaojiao Zhu, Jinsong Ding, Wenhu Zhou*, Polyserotonin as a Versatile Coating with pH-responsive Degradation for Anti-tumor Therapy, Chem. Commun., 2022,58, 6713-6716
6. Jiali Deng+, Rui Wang+, Jinsong Ding* and Wenhu Zhou*, Macrophages-Regulating Nanomedicines for Sepsis Therapy, Chinese Chemical Letters, 2022, in press
7. Lina Guo+, Shenghui Zhong+, Peng Liu, Man Guo, Jinsong Ding and Wenhu Zhou*, Radicals Scavenging MOFs Enabling Targeting Delivery of siRNA for Rheumatoid Arthritis Therapy, Small, 2022, 2202604
8. Hanane Aliouat#, Ying Peng#, Zoya Waseem, Shengfeng Wang, and Wenhu Zhou*, Pure DNA scaffolded Drug Delivery Systems for Cancer Therapy, Biomaterials, 2022, 285, 121532
9. Mengzhen Yu#, Yanwen Zhang#, Meirong Fang, Shah Jehan* and Wenhu Zhou*, Current Advances of Nanomedicines Delivering Arsenic Trioxide for Enhanced Tumor Therapy, Pharmaceutics, 2022, 14(4), 743
10. Qin Ouyang#, Kai Liu#, Qubo Zhu#, Huiyin Deng, Yuan Le, Wen Ouyang, Xiaoxin Yan, Wenhu Zhou*, Jianbin Tong, Brain-Penetration and Neuron-Targeting DNA Nanoflowers Co-Delivering miR-124 and Rutin for Synergistic Therapy of Alzheimer's Disease, Small, 2022, 2107534
11. Weidong Sun#, Yiyan Xu#, Ye Yao, Jie Yue, Zhen Wu, Haocheng Li, Guanghui Shen, Yan Liao, Haiyang Wang*, and Wenhu Zhou*, Self-oxygenation Mesoporous MnO2 Nanoparticles with Ultra-High Drug Loading Capacity for targeted Arteriosclerosis Therapy, Journal of Nanobiotechnology, 2022, 20, 88
12. Yuan Chen#, Ruiheng Luo#, Jing Li#, Shengfeng Wang, Jinsong Ding, Kai Zhao*, Ben Lu* and Wenhu Zhou*, Intrinsic Radical Species Scavenging Activities of Tea Polyphenols Nanoparticles Blocks Pyroptosis in Endotoxin-Induced Sepsis, ACS Nano, 2022, 16, 2429-2441
13. Peng Liu+, Ying Peng, Jinsong Ding and Wenhu Zhou*, Fenton Metal Nanomedicines for Imaging-guided Combinatorial Chemodynamic Therapy against Cancer, Asian Journal of Pharmaceutical Sciences, 2022, In Press
14. Yuejia Song, Yaqian Huang, Fang Zhou, Jinsong Ding*, Wenhu Zhou*, Macrophage-targeted nanomedicine for chronic diseases immunotherapy, Chinese Chemical Letters, 2022, 33, 597-612
15. Jiaojiao Zhu, Man Guo, Yanhui Cui, Yingcai Meng, Jinsong Ding, Wenbin Zeng, and Wenhu Zhou*, Surface Coating of Pulmonary siRNA Delivery Vectors Enabling Mucus Penetration, Cell Targeting, and Intracellular Radical Scavenging for Enhanced Acute Lung Injury Therapy, ACS Appl. Mater. Interfaces 2022, 14, 4, 5090–5100
16. Shah Jehan, Jiaxin Huang, Umar Farooq, Irum Basheer and Wenhu Zhou*, Combinatorial effect of thymoquinone with chemo agents for tumor therapy, Phytomedicine, 2022, 98, 153936
17. Peng Liu+, Xinyi Shi+, Ying Peng, Jianming, Hu, Jinsong Ding and Wenhu Zhou*, Anti-PD-L1 DNAzyme Loaded Photothermal Mn2+/Fe3+ Hybrid Metal-Phenolic Networks for Cyclically Amplified Tumor Ferroptosis-Immunotherapy, Advanced Healthcare Materials, 2021, 2102315
18. Shengmei Wang, Xuanjun Liu, Shengfeng Wang, Linqi Ouyang, Hui Li, Jinsong Ding, Guiming Deng*, and Wenhu Zhou*, Imatinib co-loaded targeted realgar nanocrystal for synergistic therapy of chronic myeloid leukemia, Journal of Controlled Release, 2021, 338, 190-200
19. Yang Zeng, Haiyan Zhou, Jinsong Ding, and Wenhu Zhou*, Cell membrane inspired nano-shell enabling long-acting Glucose Oxidase for Melanoma starvation therapy via microneedles-based percutaneous delivery, Theranostics, 2021; 11:8270-8282
20. Peng Liu, Yanbin Zhou, Xinyi Shi, Yu Yuan, Ying Peng, Jinsong Ding, Yong Li*, and Wenhu Zhou*, A Cyclic Nano-reactor Achieving Enhanced Photodynamic Tumor Therapy by Reversing Multiple Resistances, J. Nanobiotechnol., 2021, 19, 149
21. Peng Liu, Ying Peng, Yanbin Zhou, Xinyi Shi, Qingnian Li, Jinsong Ding, Yang Gao,* and Wenhu Zhou*, Rapamycin as a “One-Stone-Three-Birds” Agent for Cooperatively Enhanced Phototherapies Against Metastatic Breast Cancer, ACS Appl. Mater. Interfaces, 2021, 13, 22, 25674–25684
22. Peng Liu, Xinyi Shi, Shenghui Zhong, Ying Peng, Yan Qi, Jinsong Ding, Wenhu Zhou*, Metal-phenolic networks for cancer theranostics, Biomater. Sci., 2021,9, 2825-2849
23. Shenghui Zhong, Peng Liu, Jinsong Ding* and Wenhu Zhou*, Hyaluronic Acid-Coated MTX-PEI Nanoparticles for Targeted Rheumatoid Arthritis Therapy, Crystals, 2021, 11(4), 321-334
24. Man Guo, Yingcai Meng, Xiaoqun Qin*, and Wenhu Zhou*, Dopamine-Grafted Hyaluronic Acid Coated Hyperbranched Poly(β-Amino Esters)/DNA Nano-Complexes for Enhanced Gene Delivery and Biosafety, Crystals, 2021, 11(4), 347-360
25. Yang Xi, Xin Xie, Ying Peng, Peng Liu, Jinsong Ding* and Wenhu Zhou*, DNAzyme-adsorbed polydopamine@MnO2 core–shell nanocomposites for enhanced photothermal therapy via the self-activated suppression of heat shock protein 70, Nanoscale, 2021, 13, 5125-5135
26. Peng Liu, Xin Xie, Miao Liu, Shuo Hu, Jinsong Ding, Wenhu Zhou*, A Smart MnO2 Doped Graphene Oxide Nanosheet for Enhanced Chemo-Photodynamic Combinatorial Therapy via Simultaneous Oxygenation and Glutathione Depletion, Acta Pharmaceutica Sinica B, 2021, 11, 823-834
27. Yihua Yang, Lina Guo, Zhe Wang, Peng Liu, Xuanjun Liu, Jinsong Ding, Wenhu Zhou*, Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and Re-polarization, Biomaterials, 2021, 246, 120390
28. Lina Guo, Yang Chen, Ting Wang, Yu Yuan, Yihua Yang, Xiaoli Luo, Shuo Hu, Jinsong Ding* and Wenhu Zhou*, Rational design of metal-organic frameworks to deliver methotrexate for targeted rheumatoid arthritis therapy, Journal of Controlled Release, 2021, 330, 119-131
29. Ze Mi#, Lina Guo#, Peng Liu#, Yan Qi, Zhichao Feng, Jiahao Liu, Zhenhu He, Xiao Yang, Shengnan Jiang, Jianzhen Wu, Jinsong Ding, Wenhu Zhou*, and Pengfei Rong*, “Trojan Horse” Salmonella Enabling Tumor Homing of Silver Nanoparticles via Neutrophil Infiltration for Synergistic Tumor Therapy and Enhanced Biosafety, Nano letters, 2021, 21, 1, 414–423
30. Yingcai Meng, Yuan Chen, Jiaojiao Zhu, Yan Qi, Jinsong Ding, Wenhu Zhou*, Polarity Control of DNA Adsorption Enabling Surface Functionalization of CuO Nanozyme for Targeted Tumor Therapy, Materials Horizons, 2021, 8, 972-986
31. Peng Liu, Xuanjun Liu, Yan Cheng, Shenghui Zhong, Xinyi Shi, Shengfeng Wang, Jinsong Ding, Wenhu Zhou*, Core-Shell Nanosystems for Self-Activated Drug-Gene Combinations against Triple-Negative Breast Cancer, ACS Appl. Mater. Interfaces, 2020, 48, 53654-53664
32. Yunbo Nie, Dan Li, Ying Peng, Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, Metal Organic Framework Coated MnO2 Nanosheets Delivering Doxorubicin and Self-activated DNAzyme for Chemo-gene Combinatorial Treatment of Cancer, International Journal of Pharmaceutics, 2020, 585, 1195
33. Ying Peng, Peng Liu, Yingcai Meng, Jinsong Ding* and Wenhu Zhou*, Nanoscale Copper(II)-Diethyldithiocarbamate Coordination Polymer as Drug Self-delivery System for Highly Robust and Specific Cancer Therapy, Molecular Pharmaceutics, 2020, 8, 2864-2873
34. Miao Liu, Ying Peng, Yunbo Nie, Peng Liu, Shuo Hu, Jinsong Ding* and Wenhu Zhou*, Co-delivery of doxorubicin and DNAzyme using ZnO@polydopamine core-shell nanocomposites for chemo/gene/photothermal therapy, Acta Biomaterialia, 2020, 110, 242-253
35. Peng Liu, Xin Xie, Xinyi Shi, Ying Peng, Jinsong Ding and Wenhu Zhou*, Oxygen-Self-Supplying and HIF-1α-Inhibiting Core−Shell Nanosystem for Hypoxia-Resistant Photodynamic Therapy, ACS Appl. Mater. Interfaces 2019, 11, 48261−48270
36. Liang Li, Yingcai Meng, Ling Li, Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, A Tetrahedral DNA Nanoflare for Fluorometric Determination of Nucleic Acids and Imaging of MicroRNA Using Toehold Strands, Microchimica Acta, 2019, 186, 824
37. Yang Yihua, Wang Zhe, Peng Ying, Jinsong Ding* and Wenhu Zhou*, A Smart pH-Sensitive Delivery System for Enhanced Anticancer Efficacy via Paclitaxel Endosomal Escape, Frontiers in Pharmacology, 2019, DOI: 10.3389/fphar.2019.00010
38. Xiaoli Luo, Xin Xie, Yingcai Meng, Taoli Sun, Jinsong Ding* and Wenhu Zhou*, Ligands dissociation induced gold nanoparticles aggregation for colorimetric Al3+ detection, Analytica Chimica Acta, 2019, 1087, 9, 76-85
39. Shengfeng Wang, Jinsong Ding* and Wenhu Zhou*, An aptamer-tethered, DNAzyme-embedded molecular beacon for simultaneous detection and regulation of tumor-related genes in living cells, Analyst, 2019, 144, 5098-5107
40. Liu Peng, Guo Binbin, Wang Shengfeng, Jinsong Ding* and Wenhu Zhou*, A thermo-responsive and self-healing liposome-in-hydrogel system as an antitubercular drug carrier for localized bone tuberculosis therapy, International Journal of Pharmaceutics, 2019, 558, 101-109
41. Yang Chen, Cejun Yang, Juan Mao, Haigang Li, Ying, Jinsong Ding* and Wenhu Zhou*, Spermine Modified Polymeric Micelles with pH-Sensitive Drug Release for Targeted and Enhanced Antitumor Therapy, RSC Advances, 2019, 9, 11026-11037
42. Yingcai Meng, Peng Liu, Wenhu Zhou*, Jinsong Ding*, Juewen Liu, Bioorthogonal DNA Adsorption on Polydopamine Nanoparticles Mediated by Metal Coordination for Highly Robust Sensing in Serum and Living Cells, ACS Nano, 2018, 12, 9070-9080
43. Peng Liu, Shengfeng Wang, Xuanjun Liu, Jinsong Ding* and Wenhu Zhou*, Platinated graphene oxide: A nanoplatform for efficient gene-chemo combination cancer therapy, European journal of pharmaceutical sciences, 2018, 121, 319-329
44. Binbin Guo, Yuqiao Zhang, Shengfeng Wang, Jinsong Ding and Wenhu Zhou*, The pharmacokinetics of morphine and codeine in human plasma and urine after oral administration of Qiangli Pipa Syrup, Journal of forensic science, 2018, 63, 1221-1228
45. Shengfeng Wang, Chuantong Zhao, Peng Liu, Zhe Wang, Jinsong Ding* and Wenhu Zhou*, Facile construction of dual-targeting delivery system by using lipid capped polymer nanoparticles for anti-glioma therapy. RSC Advances, 2018, 8, 444–453
46. Wenhu Zhou* and Juewen Liu*, "Multi-metal-dependent nucleic acid enzymes", Metallomics, 2018, 10, 30-48
47. Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Splitting a DNAzyme enabling Na+-dependent FRET signal from the embedded aptamer", Organic & Biomolecular Chemistry, 2017, 15, 6959-6966
48. Wenhu Zhou, Runjhun Saran, Jinsong Ding and Juewen Liu*, "Two Completely Different Mechanisms for Highly Specific Na+ Recognition by DNAzymes", ChemBioChem, 2017, 18, 1828-1835
49. Wenhu Zhou, Runjhun Saran and Juewen Liu*, "Metal Sensing by DNA", Chemical Reviews, 2017, 117, 8272–8325
50. Wenhu Zhou, Runjhun Saran, Po-Jung Jimmy Huang, Jinsong Ding and Juewen Liu*, "An Exceptionally Selective DNA Cooperatively Binding Two Ca2+ Ions", ChemBioChem, 2017, 18, 518-522.
51. Wenhu Zhou, Jinsong Ding and Juewen Liu*, "Theranostic DNAzymes", Theranostics, 2017, 7, 1010-1025
52. Wenhu Zhou, Jinsong Ding and Juewen Liu*, "2-Aminopurine-modified DNA homopolymers for robust and sensitive detection of mercury and silver", Biosensors & Bioelectronics, 2017, 87, 171-177
53. Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A highly specific sodium aptamer probed by 2-aminopurine for robust Na+ sensing", Nucleic Acids Research, 2016, 44, 10377-10385
54. Wenhu Zhou, Tianmeng Yu, Mahsa Vazin, Jinsong Ding and Juewen Liu*, "Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis", Inorganic Chemistry, 2016, 55, 8193–8200
55. Wenhu Zhou, Jinsong Ding and Juewen Liu*, "A Selective Na+ Aptamer Dissected by Sensitized Tb3+ Luminescence", ChemBioChem, 2016, 17, 1563–1570
56. Wenhu Zhou, Mahsa Vazin, Tianmeng Yu Jinsong Ding and Juewen Liu*, "In Vitro Selection of Chromium-Dependent DNAzymes for Sensing Cr(III) and Cr(VI)", Chemistry, a European Journal, 2016, 22, 9835-9840
57. Wenhu Zhou, Yupei Zhang, Jinsong Ding* and Juewen Liu*, "In Vitro Selection in Serum: RNA-Cleaving DNAzymes for Measuring Ca2+ and Mg2+", ACS Sensors, 2016, 1, 600-606
58. Wenhu Zhou, Jinsong Ding and Juewen Liu*, "An Efficient Lanthanide-Dependent DNAzyme Cleaving 2’-5’ Linked RNA", ChemBioChem, 2016, 17, 890-894
59. Wenhu Zhou, Runjhun Saran, Qingyun Chen, Jinsong Ding and Juewen Liu*, "A New Na+-Dependent RNA-Cleaving DNAzyme with over 1000-fold Rate Acceleration by Ethanol", ChemBioChem, 2016, 17, 159-163
60. Wenhu Zhou, Yupei Zhang, Po-Jung Jimmy Huang, Jinsong Ding, and Juewen Liu*, "A DNAzyme requiring two different metal ions at two distinct sites", Nucleic Acids Research, 2016, 44, 354-363
61. Wenhu Zhou, Jinsong Ding* and Juewen Liu*, "A platinum shell for ultraslow ligand exchange: unmodified DNA adsorbing more stably on platinum than thiol and dithiol on gold", Chemical Communications, 2015, 51, 12084-12087
62. Wenhu Zhou, Qingyun Chen, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "DNAzyme Hybridization, Cleavage, Degradation and Sensing in Undiluted Human Blood Serum", Analytical Chemistry, 2015, 87, 4001–4007
63. Wenhu Zhou, Feng Wang, Jinsong Ding* and Juewen Liu*, "Tandem Phosphorothioate Modifications for DNA Adsorption Strength and Polarity Control on Gold Nanoparticles", ACS Applied Materials & Interfaces, 2014, 6, 14795-14800
64. Wenhu Zhou, Po-Jung Jimmy Huang, Jinsong Ding* and Juewen Liu*, "Aptamer-based biosensors for biomedical diagnostics", Analyst, 2014, 139, 2627-2640
65. Wenhu Zhou, Yanbin Zhou, Jianping Wu, Zhenbao Liu, Huanzhe Zhao, Juewen Liu*, and Jinsong Ding*. "Aptamer-nanoparticle bioconjugates enhance Intracellular delivery of vinorelbine to breast cancer cells", Journal of Drug Targeting, 2014, 22(1): 57-66
66. Wenhu Zhou, Shiying He, Yijun Yang, Dan Jian, Xiang Chen*, and Jinsong Ding*," Formulation, characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma”, Drug development and industrial pharmacy, 2015, 41 (7), 1109-1119
